A methodological proposal and tool support for the HL7 standards compliance in the development of health information systems

Health information systems are increasingly complex, and their development is presented as a challenge for software development companies offering quality, maintainable and interoperable products. HL7 (Health level 7) International, an international non-profit organization, defines and maintains standards related to health information systems. However, the modelling languages proposed by HL7 are far removed from standard languages and widely known by software engineers. In these lines, NDT is a software development methodology that has a support tool called NDT-Suite and is based, on the one hand, on the paradigm of model-driven engineering and, on the other hand, in UML that is a widely recognized standard language. This paper proposes an extension of the NDT methodology called MoDHE (Model Driven Health Engineering) to offer software engineers a methodology capable of modelling health information systems conforming to HL7 using UML domain models

Caracterización de daños histológicos ocasionados por hongos patógenos aislados del fruto de arazá (Eugenia stipitata)

En una finca ubicada al sur del municipio de Florencia-Caquetá (Colombia) se recolectaron frutos de arazá (Eugenia stipitata) que exhibían una clara sintomatología de ataque fúngico. A estos frutos se les determinó los hongos patógenos asociados a la laceración observada, además de una caracterización histológica de los daños tisulares presentes. A los frutos procesados en laboratorio se les realizó diversos cortes en exocarpo y mesocarpo para luego ser tincionados, fijados en láminas portaobjetos y observados con estereoscopio y microscopio. Los hongos se aislaron y repicaron en medio de cultivo PDA usando la técnica del microcultivo para su identificación. Se encontró evidentes daños tisulares a nivel de epidermis, estructuras esclerenquimatosas (esclereidas) e hiperplasia en el estrato de células más internas del exocarpo y mesocarpo (antracnosis). Se encontraron tres hongos asociados a la zona necrótica del fruto: Colletotrichum gloesporioides, Pestalotia sp. y Trichophyton sp. Los dos primeros son fitopatógenos: C. gloesporioides causa la antracnosis y Pestalotia es el responsable de la “roña del fruto”. Trichophyton como saprófito facultativo no causó daños en tejidos vegetales. C. gloesporioides fue el mayor responsable de los daños tisulares observados en el fruto de arazá. © 2005 Universidad de la Amazonia. Todos los derechos reservado

Platform for the automatic extraction and coding of concepts within the scope of Oncohematology (COCO Project)

El proyecto COCO tiene como objetivo diseñar, desarrollar y validar un sistema de extracción de conocimiento que, a partir de los textos de la Historia de Salud Electrónica, codifique automáticamente los diagnósticos de Oncohematología mediante Tecnologías del Lenguaje basada en un estándar de pipeline interoperable. La necesidad de normalizar el conocimiento de la Historia Clínica constituye un gran desafío. Puesto que la CIE-10 presenta limitaciones para representar esta información, se desarrolló la norma CIE-O-3, para dar soporte a este tipo de patologías. Se propone desarrollar el primer pipeline de Procesamiento del Lenguaje Natural de componentes interoperables, así como, el primer codificador automático CIE-O-3 y CIE-10. Nuestro sistema servirá de apoyo a la decisión, investigación y gestión clínica en este campo.The COCO project aims to design, develop and validate a knowledge extraction system that, based on the texts of the Electronic Health Record, automatically codes Oncohematology diagnostics using Language Technologies based on an interoperable pipeline standard. The need to standardize knowledge of the Electronic Health Record is a major challenge. Since ICD-10 has limitations in representing this information, ICD-O-3 was developed to support this type of pathology. It is proposed to develop the first Natural Language Processing pipeline of interoperable components, as well as the first ICD-O-3 and ICD-10 automatic encoder. Our system will support clinical decision making, research and management in this field.Esta investigación ha sido financiada en parte por la Plataforma de Innovación en Tecnologías Médicas y Salud (Plataforma ITEMAS, PT13/0006/0036) financiado por el Instituto de Salud Carlos III y por el proyecto COCO (PIN-0121-2017) financiado por la consejería de Salud de la Junta de Andalucía ambos cofinanciados a través de los Fondos Europeos de Desarrollo Regional (FEDER)

VOLUMEN 23, NÚMERO 38 (2001)

Callawayasaurus colombiensis (Welles) Carpenter 1999. EL PLESIOSAURIO DE VILLA DE LEYVA (BOYACÁ, COLOMBIA). ¿UN NUEVO ESPÉCIMEN?. Jerez Jaimes, J. H.; Narváez Parra, E. X.DISTRIBUCIÓN ESPACIAL Y RELACIÓN ENTRE ORGANISMOS FÓSILES. BREVE SÍNTESIS PALEOECOLÓGICA de Toxaster colombianus y Thalassinoides. Cruz Guevara, L. E., Jerez Jaimes, J. H., Narváez Parra, E. X., Franco Blanco, R. A.EDADES POR TRAZAS DE FISIÓN DE CIRCONES PROVENIENTES DE LA FORMACIÓN SALDAÑA, VALLE SUPERIOR DEL MAGDALENA. Schwabe, E; Toro, G.; Kairuz Ch.; Ferreira, POCURRENCIA, COMPOSICIÓN QUÍMICA Y SIGNIFICADO GENÉTICO DE LA BIOTITA EN LAS ROCAS METAMÓRFICAS DE LA FORMACIÓN SILGARÁ EN LA REGIÓN SUROCCIDENTAL DEL MACIZO DE SANTANDER. Ríos Reyes, C. APRIMERA OCURRENCIA DE LOS TRES POLIMORFOS DE Al2SiO5 EN LAS ROCAS METAPELÍTICAS DE LA FORMACIÓN SILGARÁ, REGIÓN SUROCCIDENTAL DEL MACIZO DE SANTANDER. Ríos Reyes, C. A.; García Ramírez, C. AESTUDIO DE LOS FLUÍDOS HIDROTERMALES ASOCIADOS A LAS MINERALIZACIONES DE FLUORITA SECTOR CEPITÁ-PESCADERO, MACIZO DE SANTANDER. Mantilla, L. C.; Quintero, C.; Mesa, A.; García Ramírez, C. A.; Bartels, H.ESTUDIO DE LOS PALEOFLUIDOS EN LA FORMACIÓN SILGARÁ Y SU RELACIÓN CON PROCESOS DE DEFORMACIÓN. SECTOR ARATOCA-PESCADERO (SW DEL MACIZO DE SANTANDER). Mantilla Figueroa, L. C.; Ordóñez Calderón, J.; Cepeda Espitia, S.; Ríos Reyes, C. A.DESARROLLO DE UNA ESQUISTOSIDAD TECTÓNICA, ASOCIADA AL PASO DE FLUIDOS HIDROTERMALES. CUENCA CRETÁCICA DE CAMEROS (LA RIOJA - ESPAÑA). Mantilla Figueroa, L. C

Ruxolitinib in refractory acute and chronic graft-versus-host disease : a multicenter survey study

Graft-versus-host disease is the main cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation. First-line treatment is based on the use of high doses of corticosteroids. Unfortunately, second-line treatment for both acute and chronic graft-versus-host disease, remains a challenge. Ruxolitinib has been shown as an effective and safe treatment option for these patients. Seventy-nine patients received ruxolitinib and were evaluated in this retrospective and multicenter study. Twenty-three patients received ruxolitinib for refractory acute graft-versus-host disease after a median of 3 (range 1-5) previous lines of therapy. Overall response rate was 69.5% (16/23) which was obtained after a median of 2 weeks of treatment, and 21.7% (5/23) reached complete remission. Fifty-six patients were evaluated for refractory chronic graft-versus-host disease. The median number of previous lines of therapy was 3 (range 1-10). Overall response rate was 57.1% (32/56) with 3.5% (2/56) obtaining complete remission after a median of 4 weeks. Tapering of corticosteroids was possible in both acute (17/23, 73%) and chronic graft-versus-host disease (32/56, 57.1%) groups. Overall survival was 47% (CI: 23-67%) at 6 months for patients with aGVHD (62 vs 28% in responders vs non-responders) and 81% (CI: 63-89%) at 1 year for patients with cGVHD (83 vs 76% in responders vs non-responders). Ruxolitinib in the real life setting is an effective and safe treatment option for GVHD, with an ORR of 69.5% and 57.1% for refractory acute and chronic graft-versus-host disease, respectively, in heavily pretreated patients

Bovine Tuberculosis in Doñana Biosphere Reserve: The Role of Wild Ungulates as Disease Reservoirs in the Last Iberian Lynx Strongholds

Doñana National Park (DNP) in southern Spain is a UNESCO Biosphere Reserve where commercial hunting and wildlife artificial feeding do not take place and traditional cattle husbandry still exists. Herein, we hypothesized that Mycobacterium bovis infection prevalence in wild ungulates will depend on host ecology and that variation in prevalence will reflect variation in the interaction between hosts and environmental risk factors. Cattle bTB reactor rates increased in DNP despite compulsory testing and culling of infected animals. In this study, 124 European wild boar, 95 red deer, and 97 fallow deer were sampled from April 2006 to April 2007 and analyzed for M. bovis infection. Modelling and GIS were used to identify risk factors and intra and inter-species relationships. Infection with M. bovis was confirmed in 65 (52.4%) wild boar, 26 (27.4%) red deer and 18 (18.5%) fallow deer. In the absence of cattle, wild boar M. bovis prevalence reached 92.3% in the northern third of DNP. Wild boar showed more than twice prevalence than that in deer (p<0.001). Modelling revealed that M. bovis prevalence decreased from North to South in wild boar (p<0.001) and red deer (p<0.01), whereas no spatial pattern was evidenced for fallow deer. Infection risk in wild boar was dependent on wild boar M. bovis prevalence in the buffer area containing interacting individuals (p<0.01). The prevalence recorded in this study is among the highest reported in wildlife. Remarkably, this high prevalence occurs in the absence of wildlife artificial feeding, suggesting that a feeding ban alone would have a limited effect on wildlife M. bovis prevalence. In DNP, M. bovis transmission may occur predominantly at the intra-species level due to ecological, behavioural and epidemiological factors. The results of this study allow inferring conclusions on epidemiological bTB risk factors in Mediterranean habitats that are not managed for hunting purposes. Our results support the need to consider wildlife species for the control of bTB in cattle and strongly suggest that bTB may affect animal welfare and conservation

Malaria vector species in Colombia: a review

Here we present a comprehensive review of the literature on the vectorial importance of the major Anopheles malaria vectors in Colombia. We provide basic information on the geographical distribution, altitudinal range, immature habitats, adult behaviour, feeding preferences and anthropophily, endophily and infectivity rates. We additionally review information on the life cycle, longevity and population fluctuation of Colombian Anopheles species. Emphasis was placed on the primary vectors that have been epidemiologically incriminated in malaria transmission: Anopheles darlingi, Anopheles albimanus and Anopheles nuneztovari. The role of a selection of local, regional or secondary vectors (e.g., Anopheles pseudopunctipennis and Anopheles neivai) is also discussed. We highlight the importance of combining biological, morphological and molecular data for the correct taxonomical determination of a given species, particularly for members of the species complexes. We likewise emphasise the importance of studying the bionomics of primary and secondary vectors along with an examination of the local conditions affecting the transmission of malaria. The presence and spread of the major vectors and the emergence of secondary species capable of transmitting human Plasmodia are of great interest. When selecting control measures, the anopheline diversity in the region must be considered. Variation in macroclimate conditions over a species' geographical range must be well understood and targeted to plan effective control measures based on the population dynamics of the local Anopheles species

XVI International Congress of Control Electronics and Telecommunications: "Techno-scientific considerations for a post-pandemic world intensive in knowledge, innovation and sustainable local development"

Este título, sugestivo por los impactos durante la situación de la Covid 19 en el mundo, y que en Colombia lastimosamente han sido muy críticos, permiten asumir la obligada superación de tensiones sociales, políticas, y económicas; pero sobre todo científicas y tecnológicas. Inicialmente, esto supone la existencia de una capacidad de la sociedad colombiana por recuperar su estado inicial después de que haya cesado la perturbación a la que fue sometida por la catastrófica pandemia, y superar ese anterior estado de cosas ya que se encontraban -y aún se encuentran- muchos problemas locales mal resueltos, medianamente resueltos, y muchos sin resolver: es decir, habrá que rediseñar y fortalecer una probada resiliencia social existente - producto del prolongado conflicto social colombiano superado parcialmente por un proceso de paz exitoso - desde la tecnociencia local; como lo indicaba Markus Brunnermeier - economista alemán y catedrático de economía de la Universidad de Princeton- en su libro The Resilient Society…La cuestión no es preveerlo todo sino poder reaccionar…aprender a recuperarse rápido.This title, suggestive of the impacts during the Covid 19 situation in the world, and which have unfortunately been very critical in Colombia, allows us to assume the obligatory overcoming of social, political, and economic tensions; but above all scientific and technological. Initially, this supposes the existence of a capacity of Colombian society to recover its initial state after the disturbance to which it was subjected by the catastrophic pandemic has ceased, and to overcome that previous state of affairs since it was found -and still is find - many local problems poorly resolved, moderately resolved, and many unresolved: that is, an existing social resilience test will have to be redesigned and strengthened - product of the prolonged Colombian social conflict partially overcome by a successful peace process - from local technoscience; As Markus Brunnermeier - German economist and professor of economics at Princeton University - indicates in his book The Resilient Society...The question is not to foresee everything but to be able to react...learn to recover quickly.Bogot